Catastrophic disruption of aerobic metabolism
IV.
Damage caused by other toxic substances
30. Franken L (1959) Étude anatomique d'un cas d'intoxication par le bromure
de méthyle. Acta Neurologica et Psychiatrica Belgica 59:375-383.
31. Goulon M, Nouailhat R, Escourolle R, Zarranz-Imirizaldu JJ, Grosbuis S,
Levy-Alcover MA (1975). Intoxication par le bromure de methyl: Trois observations,
dont une mortelle. Etude neuro-pathologique d'un cas de stupeur avec
myoclonies, suivi pendent cinq ans. Revue Neurologique (Paris) 131:445-468.
32. Troncoso JC, Johnston MV, Hess KM, Griffin JW, Price DL (1981) Model of
Wernicke's encephalopathy. Archives Of Neurology 38:350-354.
33. Oyanagi K, Ohama E, & Ikuta F. (1989). The auditory system in methyl
mercurial intoxication: a neuropathological investigation on 14 autopsy
cases in Niigata, Japan. Acta Neuropathologica
(Berlin), 77, 561-568.
34. Squier MV, Thompson J, Rajgopalan B. (1992) Case report:
neuropathology of methyl bromide intoxication. Neuropathology and Applied
Neurobiology 18: 579-584.
35. Cavanagh JB (1992) Methyl bromide intoxication and acute energy
deprivation syndromes. Neuropathology and Applied Neurobiology 18:575-578.
36. Cavanagh JB, Nolan CC (1993) The neurotoxicity of alpha-chlorohydrin in
rats and mice: II. Lesion topography and factors in selective vulnerability in acute
energy deprivation syndromes. Neuropathology and Applied Neurobiology
19:471-479.
37. Husain K, Whitworth C, Hazelrigg S, Rybak L (2003) Carboplatin-induced
oxidative injury in rat inferior colliculus. Int J Toxicol. 2003 Sep-Oct;22(5):335-42.
Methyl bromide was formerly used as a fire extinguisher,
it is still used as an herbicide.
Mercury is oto-toxic, and the neuropathological study of
Oyanagi et al. revealed its damaging effects in the brain.
Alpha-chlorohydrin was developed for possible use as a
male contraceptive.
Carboplatin is used in chemotherapy for cancer patients.
Troncoso et al. described the symmetric bilateral lesions
of the brainstem caused by pyrithiamine, a poison that
displaces thiamine at its enzyme attachment points.
Auditory impairments
prenatal perinatal
Auditory
agnosia
Highest
metabolism
Cardiac
arrest
Thiamine
deficiency
Asphyxia at birth
animal human
Alcohol
Toxic sub-
stances