The Rh factor of blood was discovered by Landsteiner and Weiner
(1940) and within a year Levine et al. (1941) that erythroblastosis fetalis
was caused by antibodies produced by Rh-negative mothers against this
factor during birth of an Rh-positive infant, which then caused hemolysis
of blood in subsequent infants. The initial technique developed to save
lives and protect the health of affected infants was total replacement of
the blood with Rh-negative blood (Diamond 1948, Pearson 1998).
From
Note: Check other open windows if this does not display in the foreground window
2- Replacement transfusion for erythroblastosis fetalis