Sleeping sickness and psychosis were often the aftermath of survivors of
the influenza epidemic of 1918. The descriptions of Buzzard and
Greenfield (1919) and Menninger (1926) indicate damage of brainstem
sites as significant in the behavioral dysfunction of influenza victims.
Gamper (1928) reported clinical and pathological findings in patients
who were habitual users of alcohol, confirming and extending the
findings of Wernicke and Korsakoff.
Craigie (1920) investigated vascularity of the brain in albino rats using
India ink injections. He found the cochlear nucleus to have the greatest
vascular network. Later investigations of cerebral blood flow and aerobic
metabolism would provide insight into why brainstem centers should be
vulnerable to infections and toxic substances.
From
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3 - Neuropathology and cerebral vascularity