23. Miller & Myers (1970, 1972)
1 - Circulatory arrest in mature monkeys
2 - Opisthotonus, pulmonary problems, and oculomotor dysfunction
3 - Residual deficits following cerebral circulatory arrest
4 - Neuropathology of circulatory arrest
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Miller and Myers investigated the effects on the brain of circulatory arrest in mature
monkeys. The heart was less resistant to asphyxia in mature monkeys than at birth.
Adult animals that survived asphyxia showed signs characteristic of "decerebration."
"Deceretbrate rigidity" was described by Sherrington over a hundred years ago
following a cut in the midbrain between the inferior and superior colliculi.
Oculomotor function (eye movement paralysis) was also disturbed in adult monkeys
subjected to asphyxia. Four categories of impairment were devised to describe the
neurological status of asphyxiated monkeys, though a hopeful statement of possible
recovery was made. In the second paper, the neuropathology of circulatory arrest
was described, and it was similar to what had been observed in monkeys
asphyxiated at birth.