24. Myers (1972)
1 - How damage to the cerebral cortex occurs
2 - Prolonged partial asphyxia
3 - Pathogenesis of cerebral palsy
4 - Sudden total asphyxia revisited
5 - The brainstem pattern of damage
6 - Impairment of mitochondria and the blood-brain barrier
7 - Blood flow in the brain
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Research
Myers did not believe the brainstem pattern of damage was relevant to any human
condition. He set out to modify conditions of oxygen insufficiency that might result
in damage to the cerebral cortex, which is known to underlie spastic cerebral palsy.
He discovered that partial oxygen insufficiency (hypoxia, rather than sudden total
asphyxia) caused damage to the cerebral cortex. Monkeys subjected to partial
circulatory insufficiency late in gestation were afflicted with cerebral palsy, and
damage in their brains involved the cerebral cortex.
Myers also reconfirmed the conditions that lead to brainstem damage. Myers also
confirmed that blood flow in the monkey brain is greatest in the same brainstem
nuclei observed earlier in the cat. Myers, further, examined brain tissue and
described breakdown in cell membranes and mitichondrial damage caused by
oxygen deprivation at birth. These findings highlight the danger of innoculations
given in the newborn nursery to infants with such tissue damage in the brain.